Shingetsutan Tsukihime

Summary (from ANN): Shiki Tohno sustained a life threatening injury as a child. Due to that incident he was sent away from the Tohno household and given to a relative to be raised. Years later, when Shiki is in high school, the head of the Tohno household – his father – dies, and he is ordered to move back in by his sister Akiha, who is the new head of the household. The day he moves back to the Tohno household is the day he stumbles upon a woman named Arcueid Brunstud and decapitates her with one stab of his knife in a temporary fit of insanity. When she suddenly showed up beside him later alive and well, and asked him to be her bodyguard, Shiki’s journey to unravel the mysteries of his past begins.

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